Re-stabilisation of the disc
One single injection of STA363 will stabilise the segment by transforming the nucleus pulposus into connective tissue and by rigidifying the anulus fibrosus. The rapid transformation will break the vicious cycle of degeneration and prevent further destabilisation.
Limitation of leakage
Annular tears allowing leakage of pain-producing agents is a proposed cause of discogenic back pain2,8,9. Pro-inflammatory substances are known to produce pain when applied to the nerve roots10,11. By transforming the disc into connective tissue, STA363 reduces both production of pain-generating molecules and their spread to nerves.